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KMID : 1159320170190040423
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Korean Journal of Vision Science
2017 Volume.19 No. 4 p.423 ~ p.432
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Risk Factors for Age-Related Macular Degeneration according to Gender in Korean Adults
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Cho Jong-Pil
Rhee Kang-Oh
Back Seung-Sun
Lee Hyun
Kim Jung-Hyun
Lee Tae-Ryong
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Abstract
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Purpose: To investigate the prevalence and risk factors of an early and late age-related macular degeneration according to gender in Korean adults.
Methods: The subjects were 7,599 (male 3,263, female 4,336) except for those with missing values in the men and women over 50 years of age who received both health survey and medical examination among 25,534 subjects surveyed in the 5th National Health and Nutrition Examination Survey (2010-2012). To investigate the risk factors of early and late age-related macular degeneration according to gender, logistic regression analysis was performed on demographic characteristics, systemic diseases, and medical examination variables with controlled age. In these results, multi-variate Logistic regression analysis was performed with only significant variables.
Results: The prevalence of the early stage of the disease is 8.8% in men, 10.3% in women. That of the late stage is 1.4% in men 0.7% in women. The odds ratio in the early stage of an age-related macular degeneration, in the case of male subjects, increased about 1.043 times when they got one year older, 1.010 times when HDL rose by 1mg/dL, 1.011 times when AST rose by 1IU/L, 1.020 times when vitamin D rose by 1ng/mL, and decreased about 0.446 times when Creatinine rose by 1mg/dL, In the case of female subjects, by comparison, the odds ratio increased about 1.080 times when they got one year older, 1.960 times in subjects with hepatitis B surface antigen positive, and decreased about 0.997 times when platelets increased by 1Thous/uL. The odds ratio in the late stage of an age-related macular degeneration, in the case of male subjects, increased about 1.083 times as they got one year older, 3.346 times in subjects with hepatitis B surface antigen positive. By comparison, that of the female subjects increased about 1.126 times when they got one year older. In addition, the odds ratio of those who had finished over high school was 2.480 times higher than those under middle school and it decreased about 0.991 times as platelets increased by 1Thous/uL.
Conclusion: Except the age factor, the risk factors of an age-related macular degeneration in the early stage of the male subjects are AST, HDL and vitamin D, and increase of creatinine was decreased in odds ratio. In the late stage, whether hepatitis B surface antigen is positive or not is an important factor. In the case of female subjects, risk factor was positive for hepatitis B surface antigen in the early stage, the level of education in the late stage. And the higher the platelet count in the early and late stages was, the lower the odds ratio was.
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KEYWORD
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Age-related macular degeneration, Prevalence, Risk factor, Gender
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